Read e-book online Antibody Fc: Chapter 11. Activating and Inhibitory FcγRs in PDF

By Falk Nimmerjahn

ISBN-10: 0123948029

ISBN-13: 9780123948021

Autoimmune issues are characterised by means of the destruction of self-tissues via the immune method. a number of checkpoints are in position to avoid autoreactivity less than general conditions. Co-expression of activating and inhibitory Fc receptors (FcRs) represents this sort of checkpoint by way of constructing a threshold for immune telephone activation. in lots of human autoimmune ailments, despite the fact that, balanced FcR expression is disturbed. research of murine version structures presents robust facts that aberrant FcR expression can lead to out of control immune responses and the initiation of autoimmune illness. This overview summarizes those information and explains how this data should be used to higher comprehend human autoimmune ailments and to strengthen novel healing strategies.

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Antibody Fc: Chapter 11. Activating and Inhibitory FcγRs in Autoimmune Disorders by Falk Nimmerjahn


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